• MARKET
  • SYSTEMS
  • APPLICATIONS
  • PRODUCT TYPE
  • WATERS ADVANTAGE

Intact mAb Mass Check Standard [186006552]

  • Product
  • Documents
  • Columns & Vials

Intact mAb Mass Check Standard [186006552]

Analysis of intact proteins by MS is a powerful approach for protein identification and assignment of protein modifications. The Intact mAb Mass Check Standard is a LC-MS standard used as a qualitative tool for intact mass analysis. This standard is designed to be used for routine MS optimization, system setup and performance testing. It is an intact mouse IgG1 protein purified by Protein-A with a known molecular weight, ideal for higher molecular weight intact mass measurements. 

It is provided in a Waters TruView™ Vial (ideal for peptides) as 1 mg of lyophilized solid (lyophilization grade sucrose is used for stabilization). Recommended solubilization is in 100ul-200ul of DI water.

Store at -20 °C immediately upon arrival.

System Performance Standards Key

Set Up

Setup standards are used upon installation of a new system, start-up of a system which has been idle for a period of time, or to re-start a system that has been moved to a new location. These standards may include multiple components within a kit which allow step by step setup and calibration, or they can be single mixtures which will enable a full system assessment and initialization.

Calibration

These standards can be used for instrument calibration. Calibration is usually performed at a frequency that minimizes the risk of being out of calibration, in addition to major events suc h as when the instrument is moved and upon any major repair. Calibration can be confirmed as often as your standard operating procedures recommend. Look for solutions to calibrate your MS mass accuracy and resolution, UV detector linearity, UV and Fluorescence detector wavelength accuracy, injector accuracy and precision, and solvent system flow rate accuracy.

Performance

Your system is comprised of many interdependent components working together. An issue with any one component can produce erroneous final results. All components performing correctly will produce results within an expected variability. Some of the system components include mobile phase, column, tubing, pumping, injecting, temperature controlling, detecting, data collection rate, and integration
parameters. An issue in any one of the components listed can affect your result.
 
Performance Check Standards should be utilized on a routine basis. This includes anytime a column is changed, a method is changed, the instrument is moved, or confirmation of system performance is desired. Confirming the performance of your system can be done on a system basis with suitability standards or per individual instrument component. Benchmark performance should be established after
calibration and confirmed regularly.

Tuning

These Mass Spectrometry solutions are used routinely and are available for every ionization mode. Use the solution to optimize the mass spectrometer setting for optimal signal either manually or through Intellistart.

Hazardous

This product contains hazardous material which requires special freight handling. Additional charges may apply.

Have a Question?

Get Expert Advice!

Contact Us | Sales Offices

Related Product

BEH200 SEC Protein Standard Mix [186006518]

The BEH200 SEC Protein Standard Mix is used for benchmarking the ACQUITY UPLC

Related Product

BEH450 SEC Protein Standard Mix [186006842]

The BEH450 SEC Protein Standard Mix is used to benchmark the ACQUITY UPLC Protein BEH SEC 450, ...

Related Product

Neutrals QC Reference Material [186006360]

The Neutrals QC Reference Material is designed for use with any chromatographic systems contai ...

Related Product

Reversed-Phase QC Reference Material [186006363]

The Reversed-Phase QC Reference Material is designed for use with any chromatographic systems ...

34 Maple Street Milford, MA USA
T: 508-478-2000
F: 508-872-1990
Sales Offices

© 2018 Waters Corporation
Terms and Conditions | Privacy Policy