Reversed-Phase QC Reference Material [186006363]

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Reversed-Phase QC Reference Material [186006363]

The Reversed-Phase QC Reference Material is designed for use with any chromatographic systems containing a UV detector. It is intended to be used as a system benchmarking standard. The Reversed-Phase QC Reference Material is significantly more complex than the Neutrals QC Reference Material in that it contains a void marker, neutral, acidic and basic compounds which could be challenging to separate. It is designed to provide this complexity and is appropriate when complex assays are routinely performed.

When used consistently and control charted, the QC Reference Material will provide:

  • Confidence in your results
  • Reduce troubleshooting and re-run time
  • Enable cross lab result comparisons.


It is adaptable to a wide variety of separation methods 


The Reversed-Phase QC Reference Material is a mixture of:

  • 0.016 mg/mL uracil
  • 0.02 mg/mL butyl paraben
  • 0.06 mg/mL naphthalene
  • 0.4 mg/mL propranolol
  • 0.34 mg/mL dipropylphthalate
  • 0.2 mg/mL acenaphthene
  • 0.1 mg/mL amitriptyline in 65/35 methanol/20 mM K2HPO4 buffer pH 7


A 2 mL solution of this reference material is provided per vial.

Store at room temperature.

  • CORTECS C18 Column, 90Å, 2.7 µm, 2.1 mm X 50 mm, 1/pk (186007365)
  • ACQUITY UPLC BEH C18 Column, 130Å, 1.7 µm, 2.1 mm X 50 mm, 1/pk (186002350)
  • LCMS Certified Vials (600000668CV)
  • TruView LCMS Certified Vials (186005666CV)

System Performance Standards Key

Set Up

Setup standards are used upon installation of a new system, start-up of a system which has been idle for a period of time, or to re-start a system that has been moved to a new location. These standards may include multiple components within a kit which allow step by step setup and calibration, or they can be single mixtures which will enable a full system assessment and initialization.


These standards can be used for instrument calibration. Calibration is usually performed at a frequency that minimizes the risk of being out of calibration, in addition to major events suc h as when the instrument is moved and upon any major repair. Calibration can be confirmed as often as your standard operating procedures recommend. Look for solutions to calibrate your MS mass accuracy and resolution, UV detector linearity, UV and Fluorescence detector wavelength accuracy, injector accuracy and precision, and solvent system flow rate accuracy.


Your system is comprised of many interdependent components working together. An issue with any one component can produce erroneous final results. All components performing correctly will produce results within an expected variability. Some of the system components include mobile phase, column, tubing, pumping, injecting, temperature controlling, detecting, data collection rate, and integration
parameters. An issue in any one of the components listed can affect your result.
Performance Check Standards should be utilized on a routine basis. This includes anytime a column is changed, a method is changed, the instrument is moved, or confirmation of system performance is desired. Confirming the performance of your system can be done on a system basis with suitability standards or per individual instrument component. Benchmark performance should be established after
calibration and confirmed regularly.


These Mass Spectrometry solutions are used routinely and are available for every ionization mode. Use the solution to optimize the mass spectrometer setting for optimal signal either manually or through Intellistart.


This product contains hazardous material which requires special freight handling. Additional charges may apply.

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